Contents
1 Introduction.................................................................................. 1
Dimitri Novitzky and David K.C. Cooper
2 Historical Aspects of the Diagnosis of Death............................. 7
Félix Bacigalupo and Daniela A. Huerta Fernández
3 The Determination of Brain Death............................................. 13
Curtis M. Keller, Boris Chulpayev,
and Michael Hoffmann
4 Legal Aspects of Brain Death and Organ Donorship............... 21
Ricky T. Munoz and Mark D. Fox
5 Ethical Issues in Organ Donation
from Brain-Dead Donors............................................................. 37
Mark D. Fox and Ricky T. Munoz
6 Pathophysiology of Brain Death in Small
Animal Models............................................................................. 55
Bernhard Floerchinger, Nicholas L. Tilney,
and Stefan G. Tullius
7 Pathophysiology of Brain Death and Effects
of Hormonal Therapy in Large Animal Models........................ 65
Dimitri Novitzky, Winston N. Wicomb,
and David K.C. Cooper
8 The Efficacy of Thyroid Hormone Therapy
in Brain-Dead Heart Donors: A Review of Thyroid
Function in Health and Disease.................................................. 91
Lawrence E. Shapiro and Tatiana Baron
9 The Inflammatory Response to Brain Death............................. 107
Anne Barklin, Christine Lodberg Hvas,
and Else Toennesen
10 The Influence of Brain Death and Intensive
Care Management on Donor Organs:
Assessment of Inflammatory Markers....................................... 121
Wayel Jassem and Susan V. Fuggle
x
Uncorrected Proof
Contents
11 Brain Death-Induced Inflammation: Possible Role
of the Cholinergic Anti-inflammatory Pathway........................ 131
Simone Hoeger and Benito A. Yard
12 Innate Immunity and Injury During Brain Death:
Opportunities for Intervention................................................... 139
Marc A. Seelen, Henri G.D. Leuvenink,
and Rutger J. Ploeg
13 Selection of the Brain-Dead Potential Organ Donor................ 147
Kadiyala V. Ravindra, Keri E. Lunsford,
and Paul C. Kuo
14 Infectious Disease Aspects of the Brain-Dead
Potential Organ Donor................................................................ 155
Nicole M. Theodoropoulos and Michael G. Ison
15 Malignancy in the Brain-Dead Organ Donor............................ 177
Michael A. Nalesnik, Ron Shapiro,
and Michael G. Ison
16 Early Clinical Experience of Hormonal Therapy
in the Brain-Dead Potential Organ Donor................................. 191
Dimitri Novitzky, Burcin Ekser,
and David K.C. Cooper
17 Assessment, Monitoring, and Management
of the Brain-Dead Potential Organ Donor in the USA............. 209
Demetrios Demetriades and Lydia Lam
18 Assessment, Monitoring, and Management
of Brain-Dead Potential Organ Donors in Europe................... 217
Gabriel J. Echeverri and Bruno G. Gridelli
19 Assessment, Monitoring, and Management
of Brain-Dead Potential Organ Donors in Australia................ 237
Peter S. Macdonald, Anders E.M. Aneman,
Deepak Bhonagiri, Daryl A. Jones, Gerry O’Callaghan,
Helen I. Opdam, William Silvester, and Geoffrey J. Dobb
20 Management of the Brain-Dead Organ Donor:
Perspectives of the Transplant Coordinator.............................. 251
Nicole T. Farina and David K.C. Cooper
21 Surgical Aspects of Thoracic and Abdominal
Organ Procurement from Brain-Dead Donors......................... 263
Michael J. Anstadt, Paul C. Kuo,
and Kadiyala V. Ravindra
22 Impact of Brain Death on Storage of the Heart........................ 283
Winston N. Wicomb, and David K.C. Cooper
xi
Uncorrected Proof
Contents
23 Impact of Brain Death on Abdominal Organs
and Allograft Preservation Strategies........................................ 289
Coney Bae, Anthony Watkins, Scot D. Henry,
and James V. Guarrera
24 Functional Repair of Brain Death-Induced Injury................... 299
Henri G.D. Leuvenink, Marc A.J. Seelen,
and Rutger J. Ploeg
25 Functional Repair of Brain Death-Injured
Donor Lungs................................................................................. 311
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
26 Thyroid Hormone Therapy to the Recipient
of a Heart from a Brain-Dead Donor......................................... 321
Dimitri Novitzky and David K.C. Cooper
27 Current and Potential Future Trends in the
Management of the Brain-Dead Organ Donor......................... 333
Octavio E. Pajaro and James K. Kirklin
28 Maximizing Utilization of the Potential Deceased
Donor: The Challenge Continues............................................... 343
Eliezer Katz
Index...................................................................................................... 355