Autor: Hutt, A.
Sleep and Anesthesia
1st Edition 2011, 200 p., 85 illus., 25 in color, hardcover

About the book:

Sleep and anesthesia seem so similar that the task of analyzing the neurological similarities and differences between the two is an obvious research postulate. Both involve the loss of consciousness, or the loss of awareness of external stimuli. Yet when we investigate further, key differences start to manifest themselves—anesthesia is drug-induced while sleep requires no external cause being only the most salient. Other fascinating questions crowd in too: do we dream while under anesthesia, and do we feel pain while sleeping? Examining neural activity associated with sleep and anesthesia can be effected at various levels, from the microscopic, single-neuron level right up to that of whole neural populations.
This book aims to reveal the underlying neural mechanisms of sleep and anesthesia by employing a range of experimental techniques and applying theoretical models of neural activity that predict the mechanisms related to both states. Of course, these models offer deeper insights if their assumptions and resulting data can be correlated to experimental findings, and it is these correlations that the book focuses on. As the outcome of workshops on anesthesia and sleep at the 2007 and 2009 Computational Neuroscience Conferences in Toronto and Berlin, the chapters lay out key theoretical issues as well as hot contemporary research topics. It also details experimental techniques on various spatial scales, such as fMRIand EEG-experiments on the macroscopic, and single-neuron and LFP measurements on the microscopic scale

Contents
1 Sleep and Anesthesia: A Consideration of States, Traits, and
Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
D. Pal and G.A. Mashour
2 Modelling Sleep and General Anaesthesia . . . . . . . . . . . . . . . 21
J.W. Sleigh, L. Voss, M.L. Steyn-Ross, D.A. Steyn-Ross, and M.T. Wilson
Part I Sleep
3 Quantitative Modeling of Sleep Dynamics . . . . . . . . . . . . . . . 45
P.A. Robinson, A.J.K. Phillips, B.D. Fulcher, M. Puckeridge,
J.A. Roberts, and C.J. Rennie
4 The Fine Structure of Slow-Wave Sleep Oscillations: from Single
Neurons to Large Networks . . . . . . . . . . . . . . . . . . . . . . . 69
A. Destexhe and D. Contreras
5 A Population Network Model of Neuronal and Neurotransmitter
Interactions Regulating Sleep–Wake Behavior in Rodent Species . . 107
C.G. Diniz Behn and V. Booth
6 Neural Correlates of Human NREM Sleep Oscillations . . . . . . . . 127
A. Foret, A. Shaffii-Le Bourdiec, V. Muto, L. Mascetti, L. Matarazzo,
C. Kussé, and P. Maquet
Part II Anesthesia
7 A Mesoscopic Modelling Approach to Anaesthetic Action on Brain
Electrical Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
D.T.J. Liley, B.L. Foster, and I. Bojak
8 Progress in Modeling EEG Effects of General Anesthesia: Biphasic
Response and Hysteresis . . . . . . . . . . . . . . . . . . . . . . . . . 167
D.A. Steyn-Ross, M.L. Steyn-Ross, J.W. Sleigh, and M.T. Wilson
xi
xii Contents
9 EEG Modeling in Anesthesia: A New Insight into Mean-Field
Approach for Delta Activity Generation . . . . . . . . . . . . . . . . 195
B. Molaee-Ardekani, M.B. Shamsollahi, and L. Senhadji
10 A Neural Population Model of the Bi-phasic EEG-Power Spectrum
During General Anaesthesia . . . . . . . . . . . . . . . . . . . . . . . 227
A. Hutt
11 In-vivo Electrophysiology of Anesthetic Action . . . . . . . . . . . . 243
F. von Dincklage and B. Rehberg
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257